CellInsight™ CX5 High-Content Screening (HCS) Platform from Thermo Fisher Scientific

Product Specs
ItemCellInsight™ CX5 High-Content Screening (HCS) Platform
CompanyThermo Fisher Scientific
Price Get Pricing Get Quote for this Product
Catalog NumberCX51110
QuantityEA
ApplicationsCell Analysis, High Content Screening, Fluorescence
SoftwareThermo Scientific™ HCS Studio™ 3.0 Cell Analysis Software
TypeHigh Content Screening Platform

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Thermo Fisher Scientific

168 Third Avenue

Waltham, MA 02451

United States

Phone: 800-678-5599

Company Profile

Website: www.thermofisher.com

(1) REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic ErrorsInternational Journal of Molecular SciencesOctober 31, 2023Faye M. Vassel, Daniel J. Laverty, Ke Bian, Cortt G. Piett, Michael T. Hemann, Graham C. Walker, Zachary D. Nagelwash with deionized water prior to fixation. Images were acquired with a 20× objective lens using the CellInsight CX5 High-Content Screening (HCS) Platform (Thermofisher) and HCS studio softwareTM (https://www.fishersci.ca/shop/products/hcs-studio-2-0-cell-analysis-software/sx000041a,

(2) Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infectionPLOS PathogensOctober 5, 2023Matilda J. Moström, Shan Yu, Dollnovan Tran, Frances M. Saccoccio, Cyril J. Versoza, Daniel Malouli, Anne Mirza, Sarah Valencia, Margaret Gilbert, Robert V. Blair, et al.IgG-Alexa Fluor 488 antibody. Nuclei were stained with DAPI for 5 minutes (Pierce) and imaged using the CellInsight CX5 High-Content Screening (HCS) platform. The 50% neutralization titer (NT50) was determined by comparing the dilution that resulted in a 50%

(3) Exercise-primed extracellular vesicles improve cell-matrix adhesion and chondrocyte healthResearch SquareJune 8, 2023Hirotaka Iijima, Kai Wang, Ella D'Amico, Wan-Yee Tang, Renee J. Rogers, John M. Jakicic, Fabrisia Ambrosiowere supplemented to human chondrocytes and incubated for 2 hours under live cell imaging (cat no. CX51110, Cellinsight CX5 HCS Platform, ThermoFisher). Chondrocytes were visualized using MitoTracker. Immunofluorescence

(4) Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergenceCell ReportsMay 30, 2023Kathryn M. Hastie, Xiaoying Yu, Fernanda Ana-Sosa-Batiz, Dawid S. Zyla, Stephanie S. Harkins, Chitra Hariharan, Hal Wasserman, Michelle A. Zandonatti, Robyn Miller, Erin Maule, et al.Instruments,https://www.douglas.co.uk CellInsight CX5 High Content Screening Platform,Thermo Fisher Scientific,Cat# CX51110 Titan Krios,Thermo Fisher Scientific,https://www.thermofisher.com/us/en/home.html Holey Carbon C-flat

(5) Temporal transcriptional control of neural induction in human induced pluripotent stem cellsFrontiers in Molecular NeuroscienceMay 5, 2023Shakti Gupta, Lucia Dutan Polit, Michael Fitzgerald, Helen A. Rowland, Divya Murali, Noel J. Buckley, Shankar Subramaniamacquired with a 20X objective with the Cell insight CX5 High Content Screen Platform (Thermo Fisher, CX51110). Expression was quantified using the bioapplication Cell Health Profiling from the iDev software package

(6) Porous Cellulose Thin Films as Sustainable and Effective Antimicrobial Surface CoatingsACS Applied Materials & InterfacesMay 3, 2023Shaojun Qi, Ioannis Kiratzis, Pavan Adoni, Aekkachai Tuekprakhon, Harriet James Hill, Zania Stamataki, Aneesa Nabi, David Waugh, Javier Rodriguez Rodriguez, Stuart Matthew Clarke, et al.(Thermo Fisher). Cells were washed with PBS and then imaged and analyzed using a Thermo Scientific CellInsight CX5 high-content screening (HCS) platform. Infected cells were scored by perinuclear fluorescence above a set threshold determined by positive

(7) Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infectionbioRxivApril 14, 2023Matilda Moström, Shan Yu, Dollnovan Tran, Frances Saccoccio, Cyril J. Versoza, Daniel Malouli, Anne Mirza, Sarah Valencia, Margaret Gilbert, Robert Blair, et al.IgG-Alexa Fluor 488 antibody. Nuclei were stained with DAPI for 5 minutes (Pierce) and imaged using the CellInsight CX5 High-Content Screening (HCS) platform. The 50% neutralization titer (NT50) was determined by comparing the dilution that resulted in a 50%

(8) Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortiumCell ReportsJanuary 31, 2023Heather M. Callaway, Kathryn M. Hastie, Sharon L. Schendel, Haoyang Li, Xiaoying Yu, Jeremy Shek, Tierra Buck, Sean Hui, Dan Bedinger, Camille Troup, et al.,GE Healthcare,Cat# 29091596 CellInsight CX5 High Content Screening Platform,Thermo Fisher Scientific,Cat# CX51110 CF400-Cu grids,Electron Microscopy Sciences,Cat# CF400-Cu

(9) Shared genetic loci for body fat storage and adipocyte lipolysis in humansScientific ReportsDecember 1, 2022AgnÃ© KulytÃ©, Veroniqa LundbÃ¤ck, Peter Arner, Rona J. Strawbridge, Ingrid Dahlmantemperature. Accumulation of intracellular lipids (Bodipy) and cell number (Hoechst) were quantified with CellInsight CX5 High Content Screening (HCS) Platform (Thermo Fischer Scientific) with integrated protocols. Total Bodipy fluorescence (lipid droplets) was

(10) Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogensScientific ReportsDecember 1, 2022Rowan Watson et al.Fisher Scientific). Cells were washed with PBS and then imaged and analysed using a Thermo Scientific CellInsight CX5 High-Content Screening (HCS) platform. Infected cells and cell viability were detected by measuring perinuclear fluorescence above a set threshold

(11) Drug-Initiated Activity Metabolomics Identifies Myristoylglycine as a Potent Endogenous Metabolite for Human Brown Fat DifferentiationMetabolitesAugust 16, 2022Carlos Guijas, Andrew To, J. Rafael Montenegro-Burke, Xavier Domingo-Almenara, Zaida Alipio-Gloria, Bernard P. Kok, Enrique Saez, Nicole H. Alvarez, Kristen A. Johnson, Gary Siuzdakwashed 3 times with 1X PBS and left in 1X PBS to be imaged. 5.4. Imaging Plates were imaged using the CellInsight CX5 High Content Screening (HCS) Platform (Thermo Fisher Scientific, Waltham, MA, USA). Parameters were set to first identify individual cells

(12) Genome-Wide Association Study Identifies Genetic Loci Associated With Fat Cell Number and Overlap With Genetic Risk Loci for Type 2 DiabetesDiabetesJune 1, 2022Agné Kulyté, Alisha Aman, Rona J. Strawbridge, Peter Arner, Ingrid A. Dahlmannumber of nuclei representing number of cells in each well. Quantification of cells was performed with CellInsight CX5 High Content Screening (HCS) Platform (Thermo Fischer Scientific, Waltham, MA) with integrated “Object detection” protocol. Measurement of

(13) Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodiesCell ReportsMay 24, 2022Adrian S. Enriquez et al.Instruments,https://www.douglas.co.uk CellInsight CX5 High Content ScreeningPlatform,Thermo Fisher Scientific,Cat# CX51110 Titan Krios,Thermo Fisher Scientific,https://www.thermofisher.com/us/en/home.html Holey Carbon C-flat

(14) Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress GranulesBiomedicinesMay 3, 2022Joni Vanneste, Thomas Vercruysse, Steven Boeynaems, Philip Van Damme, Dirk Daelemans, Ludo Van Den Bosch(CellInsight CX5 high-content screening platform, Thermo Fisher Scientific, Brussels, Belgium; catalog number: CX51110) and the Thermo Scientific HCS Studio 4.0 Cell Analysis Software. Three wells were analyzed per condition.

(15) Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replicationCell ReportsMarch 22, 2022Jingru Fang, Colette Pietzsch, George Tsaprailis, Gogce Crynen, Kelvin Frank Cho, Alice Y. Ting, Alexander Bukreyev, Juan Carlos de la Torre, Erica Ollmann SaphireSCR_014210 SparkControl™,Tecan,N/A BioRender,BioRender,https://biorender.com/; RRID: SCR_018361 Thermo Scientific™ HCS Studio Cell Analysis Software,Thermo Scientific,Cat#CX51110 ZEISS ZEN 3.4 Blue edition,ZEISS,https://www.zeiss.com/ FIJI,"(Schindelin et al., 2012)",https://imagej.net/software/fiji/;

(16) Identification of cell type specific ACE2 modifiers by CRISPR screeningPLoS pathogensMarch 1, 2022Sherman EJ, Mirabelli C, Tang VT, Khan TG, Leix K, Kennedy AA, Graham SE, Willer CJ, Tai AW, Sexton JZ, et al.anti-mouse, Thermo Fisher, A21235) and DAPI (Thermo Fisher). Plates were imaged with the Thermo Fisher CellInsight CX5 High-Content Screening (HCS) Platform with a 10X/0.45NA LUCPlan FLN objective and analyzed with a Cell Profiler pipeline. An average of ten

(17) Protocol for assessment of the efficiency of CRISPR/Cas RNP delivery to different types of target cellsPLOS ONENovember 9, 2021Marina A. Tyumentseva, Aleksandr I. Tyumentsev, Vasiliy G. AkimkinProtein delivery and genome editing efficacy assessment 2.4.1. Delivery efficacy assessment using CellInsight™ CX5 High Content Screening (HCS) Platform Post-transfection efficiency of eGFP-tagged CRISPR/Cas RNP delivery will be assessed using CellInsight™ CX5 High Content Screening (HCS) Platform

(18) The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture ModelsFrontiers in PharmacologyAugust 6, 2021Scott P. Davies et al.Fisher Scientific). After washing with PBS, cells were imaged and analyzed using a Thermo Scientific CellInsight CX5 High-Content Screening (HCS) platform. Infected cells were scored by perinuclear fluorescence above a set threshold determined by positive

(19) Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian RatsJournal of Parkinson's DiseaseAugust 2, 2021Juho-Matti Renko, Arun Kumar Mahato, Tanel Visnapuu, Konsta Valkonen, Mati Karelson, Merja H. Voutilainen, Mart Saarma, Raimo K. Tuominen, Yulia A. Sidorova6-diamidino-2-phenylindole) in PBS for 10 min at room temperature and kept in PBS until imaging with CellInsight (CX51110, Thermo Fisher Scientific) CX5 High Content Screening (HCS) using 20×magnification. The number of TH-positive

(20) TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagyNature communicationsJuly 20, 2021Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, et al.described above (immunohistochemistry and immunofluorescence staining section). Images were captured using CellInsight CX5 High-Content Screening (HCS) Platform (Thermo Fisher Scientific; software HCS Navigator Version 6.6.1). Data were analyzed using HCS Studio

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